Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis

Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells

Bone morphogenetic proteins (BMPs) - expressed in the developing retina - are known to be involved in the regulation of cell proliferation and apoptosis in several tumor entities. The objective of this study was to determine the role of the BMP4 pathway in retinoblastoma cells, which are absent in a functional retinoblastoma (RB1) gene. BMP receptors were detected in all retinoblastoma cell lin...

MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9)

There is confusion about the role that IFN-α plays in the pathogenesis of pulmonary arterial hypertension (PAH) with different investigators reporting a causative or a protective role. There is now clear evidence in PAH pathogenesis for the involvement of BMP4 and BMP9 signaling, and its disruption by mutations in BMPR2. In the present study, we investigated MxA, an IFN-α-inducible cytoplasmic ...

Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization.

Bone morphogenetic protein-2: a potential regulator in scleral remodeling

PURPOSE Bone morphogenetic protein 2 (BMP-2) is a member of the main subgroup of bone morphogenetic proteins within the transforming growth factor-beta superfamily. BMP-2 is involved in numerous cellular functions including development, cell proliferation, apoptosis, and extracellular matrix synthesis. We examined BMP-2 expression in human scleral fibroblasts (HSF) and assessed the effects of r...

مقایسه تاثیر دوزهای مختلف (BMP4)Bone Morphogenetic Protein 4 و اریتروپویتین(EPO) بر تمایز سلول‌های بنیادی جنینی موش به کلنی‌های اریتروئیدی

  چکید ه   سابقه و هدف   تمایز سلول‌های بنیادی جنینی در شرایط کشت، سیستم آزمایشی را برای بررسی اثرات فرضی فاکتورهای رشد فراهم می‌کند. امروزه پیدا کردن فاکتورهای رشد و عوامل محیطی مورد نیاز برای خون‌سازی اهمیت دارد. هدف از این مطالعه مشخص کردن اثر دوزهای مختلف EPO و BMP4 بر تمایز سلول‌های بنیادی جنینی و ارزیابی تعداد و اندازه کل کلنی‌ها و تعداد کلنی‌های اریتروئیدی بود.   مواد وروش‌ها   مطالعه ان...